Health & Biomedical Sciences Faculty Publications and Presentations
Document Type
Article
Publication Date
8-26-2025
Abstract
Introduction: The advent of effective combination antiretroviral therapy (cART) has significantly improved HIV-1 treatment, saving millions of lives. However, HAND remains a concern, particularly among aging individuals with HIV-1. The mechanisms underlying HAND are not well understood.
Methods: This study investigated the role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and its upstream regulator, signal transducer, and activator of transcription 1 (STAT1), in HAND pathology. Using the SH-SY5Y neuroblastoma cell line and HIV-infected humanized mice, we examined the effects of the cART drugs, HIV Tat protein, and HIV-1 virus on STAT1 and IFIT3 expression.
Results: The results showed that HIV-1 exposure significantly upregulated STAT1 and IFIT3, contributing to neuroinflammation.
Discussion: This study identified IFIT3 as a critical molecular marker for HAND, suggesting its potential as a therapeutic target and offering new insights into disease pathology and treatment strategies.
Recommended Citation
Das, R. K., Sahoo, N., Roy, D., Galarza, J., Camila, M., Rodrigo, H., ... & Roy, U. (2025). IFIT3 Activation Significantly Contributes to HIV-1-Associated Neurodegenerative Disorder (HAND)-Mediated Neuroinflammation. Frontiers in Immunology, 16, 1532318. https://doi.org/10.3389/fimmu.2025.1532318
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Frontiers in Immunology
DOI
10.3389/fimmu.2025.1532318
Comments
Copyright © 2025 Das, Sahoo, Roy, Xu, Galarza, Garza, Rodrigo, Duttaroy and Roy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.