Health & Biomedical Sciences Faculty Publications and Presentations
The neuron navigator 2 gene and Alzheimer’s disease
Document Type
Book Chapter
Publication Date
2020
Abstract
Alzheimer's disease, the most common type of dementia, is a chronic neurodegenerative disease that slowly destroys memory and thinking skills. The genetic heritability of Alzheimer's disease ranges from 49% to 79% based on reviews of twin and family studies. Several genes/loci have been suggested to be associated with Alzheimer's disease, among which we are interested in the neuron navigator 2 (NAV2) gene. In this review, we have summarized studies of NAV2 and the wealth of evidence demonstrating that NAV2 plays a role in cellular growth, migration, and nervous system development based on animal studies as well as genetic variants of NAV2 in human studies that showed significant association with Alzheimer's disease and age-related phenotypes (including our recent studies with three independent cohorts). Future functional, genomic, and epigenomic studies of these Alzheimer's disease–associated NAV2 variants could help us better understand the pathophysiology of the disease and its related phenotypes.
Recommended Citation
Xu, C., Su, B. B., Lozano, S., & Wang, K. (2020). Chapter 1—The neuron navigator 2 gene and Alzheimer’s disease. In C. R. Martin & V. R. Preedy (Eds.), Genetics, Neurology, Behavior, and Diet in Dementia (pp. 3–24). Academic Press. https://doi.org/10.1016/B978-0-12-815868-5.00001-3
Publication Title
Genetics, Neurology, Behavior, and Diet in Dementia
DOI
10.1016/B978-0-12-815868-5.00001-3
Comments
© 2020 Elsevier Inc.