Applications of Next-Generation Sequencing in Cancer Research and Molecular Diagnosis

Authors

KeSheng Wang, The University of Texas Rio Grande Valley
Chun Xu, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

3-17-2017

Abstract

Next-generation sequencing (NGS) technologies including DNA sequencing and RNA sequencing provide “omics” approaches to reveal genomic, transcriptomic, and epigenomic landscapes of individual cancers. A variety of genomic aberrations can be screened simultaneously, such as common and rare variants, structural variations (e.g. insertions and deletions), copy-number variation, and fusion transcripts. NGS technologies together with bioinformatics analysis, which expand our knowledge, are increasingly used to simultaneously analyze multiple genes in a cost and time-effective manner and have been applied in analyzing clinical cancer samples and offering NGS-based molecular diagnosis. Therefore, NGS is increasingly valuable as a tool for diagnosis for a number of cancers. Here we briefly introduce NGS technologies and summarize the recent applications in cancer research and molecular diagnosis in breast and prostate cancers.

Comments

© 2017 Wang K, et al.

Recommended Citation

Wang K, Xu C (2017) Applications of Next-Generation Sequencing in Cancer Research and Molecular Diagnosis. J Clin Med Genomics 5: 147. https://doi.org/10.4172/2472-128X.1000147

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Journal of Clinical & Medical Genomics Journal of Clinical & Medical GenomicsISSN:

DOI

10.4172/2472-128X.1000147