Document Type
Article
Publication Date
4-2016
Abstract
The majority of neurons in lateral septum (LS) are electrically silent at resting membrane potential. Nicotine transiently excites a subset of neurons and occasionally leads to long lasting bursting activity upon longer applications. We have observed simultaneous changes in frequencies and amplitudes of spontaneous action potentials (AP) in the presence of nicotine. During the prolonged exposure, nicotine increased numbers of spikes within a burst. One of the hallmarks of nicotine effects was the occurrences of double spikes (known also as bursting). Alignment of 51 spontaneous spikes, triggered upon continuous application of nicotine, revealed that the slope of after-depolarizing potential gradually increased (1.4 vs. 3 mV/ms) and neuron fired the second AP, termed as double spiking. A transition from a single AP to double spikes increased the amplitude of after-hyperpolarizing potential. The amplitude of the second (premature) AP was smaller compared to the first one, and this correlation persisted in regard to their duration (half-width). A similar bursting activity in the presence of nicotine, to our knowledge, has not been reported previously in the septal structure in general and in LS in particular.
Recommended Citation
Kodirov, S.A., Wehrmeister, M. & Colom, L. Nicotine-Mediated ADP to Spike Transition: Double Spiking in Septal Neurons. J Membrane Biol 249, 107–118 (2016). https://doi.org/10.1007/s00232-015-9853-2
Publication Title
Journal of Membrane Biology
DOI
10.1007/s00232-015-9853-2
Comments
Copyright © 2015, Springer Science Business Media New York. Original published version available at https://doi.org/10.1007/s00232-015-9853-2