Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer’s disease, cancer risk, and cholesterol

Authors

Yang Chen
Chun Xu, The University of Texas Rio Grande ValleyFollow
Sam Harirforoosh
Xingguang Luo
Ke-Sheng Wang, East Tennessee State University

Document Type

Article

Publication Date

1-2018

Abstract

The human receptor-type protein-tyrosine phosphatase kappa (PTPRK) gene is highly expressed in human brain and is previously associated with neuropsychiatric disorders and cancer. This study investigated the association of 52 single nucleotide polymorphisms (SNPs) in the PTPRK with the risk and age at onset (AAO) of Alzheimer’s disease (AD) in 791 AD patients and 782 controls. Five SNPs (top SNP rs4895829 with p=0.0125) were associated with the risk of AD based on a multiple logistic regression (p

Comments

Copyright © 2017 Elsevier Ltd. All rights reserved. Original published version available at https://doi.org/10.1016/j.jpsychires.2017.09.021

Recommended Citation

Chen, Y., Xu, C., Harirforoosh, S., Luo, X., & Wang, K. S. (2018). Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal of psychiatric research, 96, 65–72. https://doi.org/10.1016/j.jpsychires.2017.09.021

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Title

Journal of psychiatric research

DOI

10.1016/j.jpsychires.2017.09.021