Document Type
Article
Publication Date
8-2010
Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
Recommended Citation
Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., Macciardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A. T., Mason, A. L., Myers, R. P., Peltekian, K. M., Ghent, C. N., … Seldin, M. F. (2010). Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature genetics, 42(8), 658–660. https://doi.org/10.1038/ng.627
Publication Title
Nature Genetics
DOI
10.1038/ng.627
Comments
© 2010 Nature America, Inc. All rights reserved. Original published version available at doi.org/10.1038/ng.627