Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Authors

Xiangdong Liu
Pietro Invernizzi
Yue Lu
Roman Kosoy
Yan Lu
Ilaria Bianchi
Mauro Podda
Chun Xu, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

8-2010

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

Comments

© 2010 Nature America, Inc. All rights reserved. Original published version available at doi.org/10.1038/ng.627

Recommended Citation

Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., Macciardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A. T., Mason, A. L., Myers, R. P., Peltekian, K. M., Ghent, C. N., … Seldin, M. F. (2010). Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature genetics, 42(8), 658–660. https://doi.org/10.1038/ng.627

Publication Title

Nature Genetics

DOI

10.1038/ng.627