Document Type
Article
Publication Date
10-31-2016
Abstract
Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin receptors on myocytes to stimulate glucose transporter 4 (GLUT 4) translocation to the cell surface membrane, enhancing glucose uptake. However, an additional role of insulin that is often under-appreciated is its action to increase muscle perfusion thereby improving insulin and glucose delivery to myocytes. Either of these responses (myocyte and/or vascular) may be impaired in insulin resistance, and both impairments are apparent in type 2 diabetes, resulting in diminished glucose disposal by muscle. The aim of this review is to report on the growing body of literature suggesting that insulin-mediated control of skeletal muscle perfusion is an important regulator of muscle glucose uptake and that impairment of microvascular insulin action has important physiological consequences early in the pathogenesis of insulin resistance. This work was discussed at the 2015 Australian Physiological Society Symposium “Physiological mechanisms controlling microvascular flow and muscle metabolism”.
Recommended Citation
Keske, M.A., Dwyer, R.M., Russell, R.D., Blackwood, S.J., Brown, A.A., Hu, D., Premilovac, D., Richards, S.M. and Rattigan, S. (2017), Regulation of microvascular flow and metabolism: An overview. Clin Exp Pharmacol Physiol, 44: 143-149. https://doi.org/10.1111/1440-1681.12688
DOI
https://doi.org/10.1111/1440-1681.12688
Included in
Kinesiology Commons, Pharmacology, Toxicology and Environmental Health Commons, Physiology Commons
Comments
"This is the peer reviewed version of the following article: Keske, M.A., Dwyer, R.M., Russell, R.D., Blackwood, S.J., Brown, A.A., Hu, D., Premilovac, D., Richards, S.M. and Rattigan, S. (2017), Regulation of microvascular flow and metabolism: An overview. Clin Exp Pharmacol Physiol, 44: 143-149. https://doi.org/10.1111/1440-1681.12688, which has been published in final form at https://doi.org/10.1111/1440-1681.12688. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.