Genotyping of TGIF Polymorphisms Associated with Schizophrenia and Psychosis

Authors

George Vera Jr., University of Texas-Pan American

Date of Award

5-2010

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Dr. Jonathan H. Lieman

Second Advisor

Dr. Matthew Terry

Third Advisor

Dr. Michael Persans

Abstract

Polymorphisms in Transforming Growth β-Induced Factor (TGIF) have been found to contribute to the risk of development of psychosis and related disorders. Identifying the genes responsible for causing schizophrenia and psychosis will allow for treatment at an earlier stage of development, saving the patient problems, time, and money. The purpose of this experiment is to determine the haplotype of DNA samples obtained from earlier experiments. The DNA samples were collected from people with schizophrenia in Costa Rica, Southern Texas, and Northern Mexico. The samples were tested using 5 single nucleotide polymorphisms (SNPs) and amplified using polymerase chain reaction (PCR). Haplotypes were determined using allelic discrimination. Out of 5 SNPs, three SNPs were shown to exhibit significant association with schizophrenia, while two SNPs show significant association with psychosis

Comments

Copyright 2010 George Vera Jr. All Rights Reserved.

https://www.proquest.com/books/genotyping-tgif-polymorphisms-associated-with/docview/860382724/se-2

Granting Institution

University of Texas-Pan American