Theses and Dissertations - UTB/UTPA
Date of Award
5-2013
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Javier Macossay-Torres
Second Advisor
Dr. Narayan Bhat
Third Advisor
Dr. James Bullard
Abstract
Electrospinning is the most widely studied technique for the synthesis of nanofibers. Electrospinning is considered as one of the technologies that can produce nanosized drugs incorporated in polymeric nanofibers. In vitro and in vivo studies have demonstrated that the release rates of drugs from these nanofiber formulations are enhanced compared to those from original drug substance. This technology has the potential for enhancing the oral delivery of poorly soluble drugs [1]. The electrospun mats were made using Polycaprolactone/PCL, Poly(DL-lactide)/PDL 05 and Poly(DL-lactide-co-glycolide)/PLGA. The drugs incorporated in the electrospun fibers were 5-Fluorouracil and Rapamycin. The evidence of the drugs being embedded in the polymers was obtained by scanning electron microscopy (SEM), Raman and infrared spectroscopy. The release of 5-Fluorouracil and Rapamycin were followed by UV-VIS spectroscopy.
Granting Institution
University of Texas-Pan American
Comments
Copyright 2013 Indrani Banik. All Rights Reserved.
https://www.proquest.com/dissertations-theses/electrospinning-nanofibers-controlled-drug/docview/1412699194/se-2