School of Mathematical & Statistical Sciences Faculty Publications

A Data-Driven Mathematical Model for Clonorchiasis with Seasonality

Document Type

Article

Publication Date

9-3-2025

Abstract

Clonorchiasis is a foodborne disease caused by parasites and transmitted to humans through intermediate hosts. Clonorchis sinensis parasitizes in the bile ducts of human liver and causes organ lesions. The cercariae and metacercaria of Clonorchis sinensis have seasonal variations and may be affected by high water temperature in summer. We formulate a partial differential equations (PDE) model which incorporates seasonality, spatial heterogeneity and the extrinsic incubation period (EIP) of the parasite. We present the basic reproduction number R0 and discuss the global dynamics of the model. Particularly, we choose parameters to fit the Clonorchiasis epidemic data in Guangxi, China. Our study indicates that the basic reproduction number of cases of clonorchiasis in Guangxi is R0=1.025 and the number of existing infection cases is still very large, if the prevention and control measures of Clonorchiasis are not strengthened.

Comments

https://rdcu.be/e3UUi

Publication Title

Bulletin of Mathematical Biology

DOI

10.1007/s11538-025-01527-w

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