Document Type


Publication Date



Introduction: Spinal Cord Injuries (SCI) are catastrophic injury to spinal neurons that cause a tremendous socioeconomic and public health burden on individuals globally. The role of fatty acids in treatment of SCI is not well understood and poorly standardized across treatment provision. This review seeks to explore the role of fatty acids in neurorecovery and propose emerging themes in SCI treatment with fatty acids.

Methods: A PICO was designed and online databases were searched for relevant articles. A total of 55 studies were deemed appropriate for the review and summarized into thematic elements including ) Cellular Transport 2) Neuroprotection 3) SCI Treatment.

Results: Polyunsaturated Fatty Acids (PUFAs) were the primary treatment of interest and demonstrated overall beneficial effect on neuroregeneration and SCI recovery. No consensus was found between selection, dosing, and measurement of SCI treatment outcomes in studies between 1982 and 2023.

Discussion: Publication biases were substantiated in systematic review of studies pertaining to PUFAs and SCI; further research is needed to understand the role of fatty acids and SCI treatment.

Academic Level

medical student

Mentor/PI Department




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.