MEDI 9331 Scholarly Activities Clinical Years
Document Type
Abstract
Publication Date
Summer 7-1-2025
Abstract
Migraine is a prevalent neurological disorder characterized by recurrent headaches and a range of neurological symptoms. This review examines the neurophysiological mechanisms linking migraine pathophysiology to cognitive impairment and the subjective experience of brain fog. The review synthesizes findings from neuroimaging, electrophysiology, and experimental models. Key mechanisms, including cortical spreading depression, neuroinflammation, neurotransmitter imbalances, and hemodynamic alteration,s are discussed. The review identifies the neuroanatomical structures and networks involved and describes the patterns of cognitive change observed across the migraine spectrum. Cognitive impairment and brain fog are significant aspects of migraine, extending beyond the headache phase. A distributed network of brain regions is implicated, and mental performance fluctuates across the migraine cycle.
Recommended Citation
Campos, Manny Edward, "The Neurophysiological Basis of Cognitive Impairment and Brain Fog in Migraine: A Literature Review" (2025). MEDI 9331 Scholarly Activities Clinical Years. 92.
https://scholarworks.utrgv.edu/som9331/92
Academic Level
medical student
Mentor/PI Department
Neuroscience
