Recent advances on the role of long non-coding RNAs in Alzheimer’s disease

Authors

Kyle Doxtater
Manish K. Tripathi, The University of Texas Rio Grande Valley
Mohammad Moshahid Khan

Document Type

Article

Publication Date

6-2020

Abstract

Dementia is a progressive cognitive impairment that affects the activities of daily living. Alzheimer’s disease (AD) is the most common form of the dementia worldwide accounting for 60–80% of all dementia cases. With an estimated cost exceeding $290 billion in the USA, understanding and development of future therapeutic strategies is vital. In this perspective, we will be examining the current thinking of AD research and therapeutic strategies, while proposing a possible new direction for diagnosis, understanding, and treatment targets. Non-coding RNA accounts for the largest population of the human transcriptome. Long noncoding RNA (lncRNA) is a recent molecule of interest in the biomedical research which is non protein coding and is of length greater than 200 nucleotides. LncRNAs have been shown to play diverse roles within the cells such as posttranscriptional and posttranslational regulation, chromatin modulation, and protein complex organization. Given the flexible and diverse role in disease pathophysiology, lncRNAs may serve as novel therapeutic targets for diagnosis and treatment. Evidently, recent studies showed that dysregulation of lncRNA influences the clinical course of tumorigenesis, neurological disorders, cardiovascular disease, diabetes, and acquired immunodeficiency syndrome (Kazimierczyk et al., 2020). This indicates that lncRNA can provide a unique avenue of research and possible therapeutic targets in AD.

Comments

Original published version available at doi.org/10.4103/1673-5374.284990

Recommended Citation

Doxtater, K., Tripathi, M. . K., & Khan, M. M. (2020). Recent advances on the role of long non-coding RNAs in Alzheimer’s disease. Neural Regeneration Research, 15(12), 2253. https://doi.org/10.4103/1673-5374.284990

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

First Page

2253

Last Page

2254

Publication Title

Neural Regeneration Research

DOI

10.4103/1673-5374.284990

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology