School of Medicine Publications and Presentations
Document Type
Article
Publication Date
4-9-2023
Abstract
Indocyanine green (ICG) is one of the FDA-approved near infra-red fluorescent (NIRF) probes for cancer imaging and image-guided surgery in the clinical setting. However, the limitations of ICG include poor photostability, high concentration toxicity, short circulation time, and poor cancer cell specificity. To overcome these hurdles, we engineered a nanoconstruct composed of poly (vinyl pyrrolidone) (PVP)-indocyanine green that is cloaked self-assembled with tannic acid (termed as indocyanine green-based glow nanoparticles probe, ICG-Glow NPs) for the cancer cell/tissue-specific targeting. The self-assembled ICG-Glow NPs were confirmed by spherical nanoparticles formation (DLS and TEM) and spectral analyses. The NIRF imaging characteristic of ICG-Glow NPs was established by superior fluorescence counts on filter paper and chicken tissue. The ICG-Glow NPs exhibited excellent hemo and cellular compatibility with human red blood cells, kidney normal, pancreatic normal, and other cancer cell lines. An enhanced cancer-specific NIRF binding and imaging capability of ICG-Glow NPs was confirmed using different human cancer cell lines and human tumor tissues. Additionally, tumor-specific binding/accumulation of ICG-Glow NPs was confirmed in MDA-MB-231 xenograft mouse model. Collectively, these findings suggest that ICG-Glow NPs have great potential as a novel and safe NIRF imaging probe for cancer cell/tumor imaging. This can lead to a quicker cancer diagnosis facilitating precise disease detection and management.
Recommended Citation
Chauhan, N., Cabrera, M., Chowdhury, P., Nagesh, P.K.B., Dhasmana, A., Pranav, , Jaggi, M., Chauhan, S.C., Yallapu, M.M. (2023). Indocyanine Green-based Glow Nanoparticles Probe for Cancer Imaging. Nanotheranostics, 7(4), 353-367. https://doi.org/10.7150/ntno.78405.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Nanotheranostics
DOI
10.7150/ntno.78405
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.