School of Medicine Publications and Presentations
Document Type
Article
Publication Date
3-8-2017
Abstract
One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.
Recommended Citation
Ssentongo, P., Robuccio, A. E., Thuku, G., Sim, D. G., Nabi, A., Bahari, F., ... & Schiff, S. J. (2017). A murine model to study epilepsy and SUDEP induced by malaria infection. Scientific reports, 7(1), 43652. https://doi.org/10.1038/srep43652
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Scientific Reports
DOI
10.1038/srep43652
Academic Level
faculty
Mentor/PI Department
Neurology
Comments
Copyright © 2017, The Author(s)