School of Medicine Publications and Presentations
Document Type
Article
Publication Date
1-1-2017
Abstract
Psychopharmacological research, if properly designed, may offer insight into both timing and area of effect, increasing our understanding of the brain's neurotransmitter systems. For that purpose, the acute influence of the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was repeatedly measured in 12 healthy young volunteers with resting state functional magnetic resonance imaging (RS-fMRI). Eighteen RS-fMRI scans were acquired per subject during this randomized, double blind, placebo-controlled, crossover study. Within-group comparisons of voxelwise functional connectivity with 10 functional networks were examined (P < 0.05, FWE-corrected) using a non-parametric multivariate approach with cerebrospinal fluid, white matter, heart rate, and baseline measurements as covariates. Although both compounds did not change cognitive performance on several tests, significant effects were found on connectivity with multiple resting state networks. Serotonergic stimulation primarily reduced connectivity with the sensorimotor network and structures that are related to self-referential mechanisms, whereas galantamine affected networks and regions that are more involved in learning, memory, and visual perception and processing. These results are consistent with the serotonergic and cholinergic trajectories and their functional relevance. In addition, this study demonstrates the power of using repeated measures after drug administration, which offers the chance to explore both combined and time specific effects. Hum Brain Mapp 38:308-325, 2017. © 2016 Wiley Periodicals, Inc.
Recommended Citation
Klaassens, B. L., Rombouts, S. A., Winkler, A. M., van Gorsel, H. C., van der Grond, J., & van Gerven, J. M. (2017). Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation. Human brain mapping, 38(1), 308–325. https://doi.org/10.1002/hbm.23362
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
First Page
308
Last Page
325
Publication Title
Human brain mapping
DOI
10.1002/hbm.23362
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2016 The Authors