A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Authors

Stephen M. Smith
Thomas E. Nichols
Diego Vidaurre
Anderson M. Winkler, The University of Texas Rio Grande ValleyFollow
Timothy E J Behrens
Matthew F. Glasser
Kamil Ugurbil
Deanna M. Barch
David C. Van Essen
Karla L. Miller

Document Type

Article

Publication Date

11-1-2015

Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

Comments

Original published version available at https://doi.org/10.1038/nn.4125

Recommended Citation

Smith, S. M., Nichols, T. E., Vidaurre, D., Winkler, A. M., Behrens, T. E., Glasser, M. F., ... & Miller, K. L. (2015). A positive-negative mode of population covariation links brain connectivity, demographics and behavior. Nature neuroscience, 18(11), 1565-1567. https://doi.org/10.1038/nn.4125

First Page

1565

Last Page

7

Publication Title

Nature neuroscience

DOI

10.1038/nn.4125

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics