Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data

Authors

Peter Kochunov
Neda Jahanshad
Daniel Marcus
Anderson M. Winkler, The University of Texas Rio Grande ValleyFollow
Laura Almasy
Joanne E. Curran, The University of Texas Rio Grande Valley
Ravi Duggirala, The University of Texas Rio Grande Valley
Peter T. Fox
Rene L. Olvera
John Blangero, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

5-1-2015

Abstract

The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h(2)=0.53-0.90, p

Comments

Original published version available at https://doi.org/10.1016/j.neuroimage.2015.02.050

Recommended Citation

Kochunov, P., Jahanshad, N., Marcus, D., Winkler, A., Sprooten, E., Nichols, T. E., Wright, S. N., Hong, L. E., Patel, B., Behrens, T., Jbabdi, S., Andersson, J., Lenglet, C., Yacoub, E., Moeller, S., Auerbach, E., Ugurbil, K., Sotiropoulos, S. N., Brouwer, R. M., Landman, B., … Van Essen, D. C. (2015). Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage, 111, 300–311. https://doi.org/10.1016/j.neuroimage.2015.02.050

First Page

300

Last Page

11

Publication Title

NeuroImage

DOI

10.1016/j.neuroimage.2015.02.050

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics