Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

Authors

Anna J. Jasinska
Ivette Zelaya
Susan K. Service
Christine B. Peterson
Rita M. Cantor
Oi-Wa Choi
Joseph DeYoung
Eleazar Eskin
Lynn A. Fairbanks
John Blangero, The University of Texas Rio Grande Valley
Thomas D. Dyer, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

12-2017

Abstract

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.

Comments

© 2017, Springer Nature. Original published version available at https://doi.org/10.1038/ng.3959

Recommended Citation

Jasinska, A., Zelaya, I., Service, S. et al. Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet 49, 1714–1721 (2017). https://doi.org/10.1038/ng.3959

First Page

1714

Last Page

1721

Publication Title

Nature Genetics

DOI

10.1038/ng.3959

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics