Genome-wide Linkage on Chromosome 10q26 for a Dimensional Scale of Major Depression

Authors

Emma E. M. Knowles
Jack W. Kent Jr.
D. Reese McKay
Emma Sprooten
Samuel R. Mathias
Joanne E. Curran, The University of Texas Rio Grande Valley
Melanie A. Carless
Marcio A.A. de Almeida
Harald H. H. Goring, The University of Texas Rio Grande Valley
Thomas D. Dyer, The University of Texas Rio Grande Valley
Rene L. Olvera
Peter T. Fox
Ravindranath Duggirala, The University of Texas Rio Grande Valley
Laura Almasy, The University of Texas Rio Grande Valley
John Blangero, The University of Texas Rio Grande Valley
David C. Glahn

Document Type

Article

Publication Date

2-2016

Abstract

Major depressive disorder (MDD) is a common and potentially life-threatening mood disorder. Identifying genetic markers for depression might provide reliable indicators of depression risk, which would, in turn, substantially improve detection, enabling earlier and more effective treatment. The aim of this study was to identify rare variants for depression, modeled as a continuous trait, using linkage and post-hoc association analysis. The sample comprised 1221 Mexican–American individuals from extended pedigrees. A single dimensional scale of MDD was derived using confirmatory factor analysis applied to all items from the Past Major Depressive Episode section of the Mini-International Neuropsychiatric Interview. Scores on this scale of depression were subjected to linkage analysis followed by QTL region-specific association analysis. Linkage analysis revealed a single genome-wide significant QTL (LOD=3.43) on 10q26.13, QTL-specific association analysis conducted in the entire sample revealed a suggestive variant within an intron of the gene LHPP (rs11245316, p=7.8×10−04; LD-adjusted Bonferroni-corrected p=8.6×10−05). This region of the genome has previously been implicated in the etiology of MDD; the present study extends our understanding of the involvement of this region by highlighting a putative gene of interest (LHPP).

Comments

© 2015 Elsevier B.V. All rights reserved. Original published version available at https://doi.org/10.1016/j.jad.2015.11.012

Recommended Citation

Knowles, E. E. M., Kent, J. W., McKay, D. R., Sprooten, E., Mathias, S. R., Curran, J. E., Carless, M. A., de Almeida, M. A. A., Harald, H. H. G., Dyer, T. D., Olvera, R. L., Fox, P. T., Duggirala, R., Almasy, L., Blangero, J., & Glahn, D. C. (2016). Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression. Journal of Affective Disorders, 191, 123–131. https://doi.org/10.1016/j.jad.2015.11.012

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

First Page

123

Last Page

131

Publication Title

Journal of Affective Disorders

DOI

10.1016/j.jad.2015.11.012

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics