School of Medicine Publications and Presentations
Document Type
Article
Publication Date
12-2023
Abstract
Anchorage-independent survival after intravasation of cancer cells from the primary tumor site represents a critical step in metastasis. Here, we reveal new insights into how MUC13-mediated anoikis resistance, coupled with survival of colorectal tumor cells, leads to distant metastasis. We found that MUC13 targets a potent transcriptional coactivator, YAP1, and drives its nuclear translocation via forming a novel survival complex, which in turn augments the levels of pro-survival and metastasis-associated genes. High expression of MUC13 is correlated well with extensive macrometastasis of colon cancer cells with elevated nuclear YAP1 in physiologically relevant whole animal model systems. Interestingly, a positive correlation of MUC13 and YAP1 expression was observed in human colorectal cancer tissues. In brief, the results presented here broaden the significance of MCU13 in cancer metastasis via targeting YAP1 for the first time and provide new avenues for developing novel strategies for targeting cancer metastasis.
Recommended Citation
Doxtater, K., Tripathi, M. K., Sekhri, R., Hafeez, B. B., Khan, S., Zafar, N., Behrman, S. W., Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2023). MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Life science alliance, 6(12), e202301975. https://doi.org/10.26508/lsa.202301975
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Life science alliance
DOI
10.26508/lsa.202301975
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
© 2023 Doxtater et al.
This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/ licenses/by/4.0/).