One-step simultaneous liquid phase exfoliation-induced chirality in graphene and their chirality-mediated microRNA delivery

Authors

Pranav, The University of Texas Rio Grande Valley
Eswara N. H. K. Ghali, The University of Texas Rio Grande Valley
Neeraj Chauhan, The University of Texas Rio Grande Valley
Rahul Tiwari, The University of Texas Rio Grande Valley
Subhash C. Chauhan, The University of Texas Rio Grande Valley
Murali M. Yallapu, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

10-4-2023

Abstract

Graphene (G) has established itself as an exciting prospect for a broad range of applications owing to its remarkable properties. Recent innovations in chiral nanosystems have led to sensors, drug delivery, catalysis, etc. owing to the stereospecific interactions between various nanosystems and enantiomers. As the molecular structure of G itself is achiral introducing chirality in G by simple attachment of a functional group (a chiral ligand) on the G nanosheet may result in more diverse applications. Herein, we demonstrate direct liquid phase exfoliation and chiral induction in G nanosheets abbreviated as L-graphene and D-graphene in the presence of chiral L-tyrosine and D-tyrosine and by applying high-temperature sonication. The obtained exfoliated nanosheets demonstrated stable chirality confirmed by circular dichroism. Fourier transform infrared (FTIR) spectra, Raman spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and differential scanning calorimetry (DSC) showed functional, structural, morphological, surface, and thermal characteristics of L-graphene and D-graphene. The hemo-compatibility of these chiral graphenes was evaluated for the very first time utilizing human red blood cells. Lastly, for the very first time, an attempt was made to explore enantiomeric binding between chiral L-graphene and D-graphene with microRNA (miR-205) and their possibility towards chirality-mediated gene delivery in prostate cancerous cells.

Comments

© 2023 The Author(s).

Recommended Citation

Pranav, Ghali, E. N., Chauhan, N., Tiwari, R., Cabrera, M., Chauhan, S. C., & Yallapu, M. M. (2023). One-step simultaneous liquid phase exfoliation-induced chirality in graphene and their chirality-mediated microRNA delivery. Materials Advances. https://doi.org/10.1039/D3MA00611E

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Materials Advances

DOI

10.1039/D3MA00611E

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology