School of Medicine Publications and Presentations
Document Type
Conference Proceeding
Publication Date
7-17-2023
Abstract
Background: Hippocampal formation atrophy is a well-established imaging biomarker of several neurological diseases, including Alzheimer's disease, temporal lobe epilepsy, and schizophrenia. The hippocampus is divided into subfields that have different functions and vary in sensitivity to different diseases. This study investigates the potential interaction between COVID-19 and the various hippocampus subfields, which may shed light on the long-term neurological consequences of the virus.
Method: We obtained high-resolution T1-weighted (T1w) and T2-weighted (T2w) MRI images using 7T scanners located at three sites in two countries: Pittsburgh (n=14) and Texas (San Antonio and Houston) (n=40) in the USA, and Nottingham, UK (n=33). We evaluated the hippocampus subfields using the ASHS package [1-3]. Imaging sets of 51 subjects with minimal or no manual segmentation corrections (Figures 1 and 2) were included in the analysis. We conducted T-tests with Bonferroni correction, adjusting for age and intracranial volume to identify the differences in hippocampus subfield volumes across groups.
Result: Participants who needed admission into the ICU due to Covid-19 showed a significantly lower (p-value=0.0034) left CA1 volume compared to participants who did not require ICU (Figure 3). In addition, several other non-significant trends were observed.
Conclusion: Our preliminary findings suggest that Covid-19 may impact the hippocampus, particularly in patients who required intensive care. However, the study - as of to date - has a small sample size and lacks a comparison group with patients who were admitted into ICU for acute illnesses other than Covid-19. Additionally, longitudinal data is needed to track the long-term effects of the disease on the hippocampal subfields.
Recommended Citation
Santini, T., Alkateeb, S., Liou, J.-J., Li, J., Adeyemi, O. F., Erausquin, G. A. de, Garbarino, V. R., Goss, M., Habes, M., Himali, J. J., Karmonik, C., Li, K., Masdeu, J. C., Nair, R. R., Patel, V. N., Snitz, B. E., Bowtell, R., Penny, G., Roman, G. C., … Ibrahim, T. (2023, July 17). Hippocampal subfield volumes in COVID-19: A preliminary multicenter study using 7T MRI. Alzheimer’s Association International Conference. https://alz.confex.com/alz/2023/meetingapp.cgi/Paper/82651
Publication Title
Alzheimer’s Association International Conference
Academic Level
faculty
Comments
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University of Texas Health Science Center at San Antonio