School of Medicine Publications and Presentations
Exome array analysis suggests an increased variant burden in families with schizophrenia
Document Type
Article
Publication Date
7-2017
Abstract
The exome array assays rare-but-recurrent, likely deleterious, exonic variants and represents an intermediary between single nucleotide polymorphism (SNP) arrays and sequencing for genetic association studies. Multiplex families with multiple affected individuals may be enriched for disease-associated variants of this class compared to unrelated populations. We present an exome array study of schizophrenia in 99 multiplex families (n=341, including 118 cases) from the Western Australian Family Study of Schizophrenia (WAFSS). Compared to 55,726 individuals from the DIAGRAM sample not selected for schizophrenia, overall allele frequency of exome variants was higher in the WAFSS (P
Recommended Citation
McCarthy, N. S., Melton, P. E., Ward, S. V., Allan, S. M., Dragovic, M., Clark, M. L., Morar, B., Rubio, J. P., Blangero, J., Badcock, J. C., Morgan, V. A., Moses, E. K., & Jablensky, A. (2017). Exome array analysis suggests an increased variant burden in families with schizophrenia. Schizophrenia research, 185, 9–16. https://doi.org/10.1016/j.schres.2016.12.007
Publication Title
Schizophrenia research
DOI
10.1016/j.schres.2016.12.007
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
Copyright © 2016 Elsevier B.V. All rights reserved.