School of Medicine Publications and Presentations

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  • TX-YDSRN will improve understanding of youth with depression and suicidal behaviors.

  • TX-YDSRN consists of the UT Southwestern Network Hub and 12 medical school “Nodes”.

  • The Research Registry will follow 2500 Texas youth for 2 years.

  • This report includes the first 1000 youth enrolled in the Research Registry study.



American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.


TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school “Nodes” (manage/implement study), each with 1–5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8–20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.


Among 1000 participants, 68.7 % were 12–17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12–17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of childrenGeneralized Anxiety Disorder[GAD-7]: 11.3 ± 5.9).


The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.


The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.


Under a Creative Commons license

Publication Title

Journal of Affective Disorders



Academic Level


Mentor/PI Department


Included in

Psychiatry Commons



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