School of Medicine Publications and Presentations
Document Type
Article
Publication Date
10-2023
Abstract
Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring the major pathways of JAK2/STAT3 and PI3K/AKT/mTOR and summarizing the current therapeutic interventions and strategies for glioma treatment. These treatments will be evaluated on their potential for autophagy induction and the challenges associated with their utilization. By understanding the mechanism of autophagy, clinical applications for future therapeutics in treating gliomas can be better targeted.
Recommended Citation
Chen, J., Rodriguez, A. S., Morales, M. A., & Fang, X. (2023). Autophagy Modulation and Its Implications on Glioblastoma Treatment. Current issues in molecular biology, 45(11), 8687–8703. https://doi.org/10.3390/cimb45110546
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Current Issues in Molecular Biology
DOI
10.3390/cimb45110546
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
Copyright © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).