School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2-8-2024
Abstract
Introduction: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.
Methods: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.
Result: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile.
Discussion: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.
Recommended Citation
Melgarejo, J. D., Gurel, K., Compton, C. R., Liu, M., Guzman, V., Assuras, S., Levin, B. E., Elkind, M. S. V., Ikram, M. K., Kavousi, M., Ikram, M. A., Wright, C., Crivello, F., Laurent, A., Tzourio, C., Vernooij, M. W., Rundek, T., Zhang, Z. Y., Bos, D., & Gutierrez, J. (2024). Brain artery diameters and risk of dementia and stroke. Alzheimer's & dementia : the journal of the Alzheimer's Association, 10.1002/alz.13712. Advance online publication. https://doi.org/10.1002/alz.13712
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Alzheimer's & dementia : the journal of the Alzheimer's Association
DOI
10.1002/alz.13712
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.