
School of Medicine Publications and Presentations
Document Type
Article
Publication Date
4-2024
Abstract
Introduction: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.
Methods: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.
Result: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile.
Discussion: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.
Recommended Citation
Melgarejo, J. D., Gurel, K., Compton, C. R., Liu, M., Guzman, V., Assuras, S., ... & Gutierrez, J. (2024). Brain artery diameters and risk of dementia and stroke. Alzheimer's & Dementia, 20(4), 2497-2507. https://doi.org/10.1002/alz.13712
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Alzheimer's & dementia : the journal of the Alzheimer's Association
DOI
10.1002/alz.13712
Academic Level
faculty
Mentor/PI Department
Neuroscience

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Comments
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.