School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2-8-2024
Abstract
A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with symptoms after a median delay of 39 days.
Recommended Citation
Strong, N., Meeks, G., Sheth, S. A., McCullough, L., Villalba, J. A., Tan, C., Barreto, A., Wanger, A., McDonald, M., Kan, P., Shaltoni, H., Campo Maldonado, J., Parada, V., Hassan, A. E., Reagan-Steiner, S., Chiller, T., Gold, J. A. W., Smith, D. J., & Ostrosky-Zeichner, L. (2024). Neurovascular Complications of Iatrogenic Fusarium solani Meningitis. The New England journal of medicine, 390(6), 522–529. https://doi.org/10.1056/NEJMoa2308192
Publication Title
New England Journal of Medicine
DOI
10.1056/nejmoa2308192
Academic Level
faculty
Mentor/PI Department
Neurology
Comments
Copyright © 2024 Massachusetts Medical Society. All rights reserved.