Diversity-Oriented Synthesis of Novel Benzimidazoles as Antimalarial agents via post Ugi MCR

Authors

Anshu Dandia
Pankaj Potlia
Irfan Khan
Vivek Kumar Kashyap, The University of Texas Rio Grande Valley
Ved Prakash Verma
Mankiva Karnatak
Anupam Dhasmana, The University of Texas Rio Grande Valley
Shashi Pandey
Tarun Shrimali
Vijay Parewa
Shahnawaz Khan
Jaybir Singh

Document Type

Article

Publication Date

2019

Abstract

An efficient strategy for the syntheses of highly diverse benzimidazoles in exceptional yields via post Ugi reactions has been described. In our methodology we have utilized isocyanide based Ugi-reaction followed by acid catalyzed condensation cyclization reaction under microwave irradiations. All benzimidazole derivatives showed moderate to good antimalarial activity when compared with chloroquine as reference compound. Among these compounds, three of them (8b), (8c), (8d) were found to be most potent towards antimalarial activity. The synthesized hybrids were examined for their purity with the help of thin layer chromatography. Different analytical techniques were employed for further characterization like Mass studies, NMRs (1H and 13C) and FT-IR.

Comments

© Chemistry & Biology Interface is the property of Indian Society of Chemists & Biologists. Original published version available here.

Recommended Citation

Dandia, A., Potlia, P., Khan, I., Kumar, V., Verma, V. P., Karnatak, M., & Dhasmana, A. (2019). Diversity-Oriented Synthesis of Novel Benzimidazoles as Antimalarial agents via post Ugi MCR. Chemistry & Biology Interface, 9(4), 9.

Publication Title

Chemistry & Biology Interface

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology