School of Medicine Publications and Presentations
Document Type
Article
Publication Date
6-29-2024
Abstract
Objective:
A high office blood pressure (BP) is associated with cognitive decline. However, evidence of 24-h ambulatory BP monitoring is limited, and no studies have investigated whether longitudinal changes in 24-h BP are associated with cognitive decline. We aimed to test whether higher longitudinal changes in 24-h ambulatory BP measurements are associated with cognitive decline.
Methods:
We included 437 dementia-free participants from the Maracaibo Aging Study with prospective data on 24-h ambulatory BP monitoring and cognitive function, which was assessed using the selective reminding test (SRT) and the Mini-Mental State Examination (MMSE). Using multivariate linear mixed regression models, we analyzed the association between longitudinal changes in measures of 24-h ambulatory BP levels and variability with cognitive decline.
Results:
Over a median follow-up of 4 years (interquartile range, 2–5 years), longitudinal changes in 24-h BP level were not associated with cognitive function (P ≥ 0.09). Higher longitudinal changes in 24-h and daytime BP variability were related to a decline in SRT-delayed recall score; the adjusted scores lowered from −0.10 points [95% confidence interval (CI), −0.16 to −0.04) to −0.07 points (95% CI, −0.13 to −0.02). We observed that a higher nighttime BP variability during follow-up was associated with a decline in the MMSE score (adjusted score lowered from −0.08 to −0.06 points).
Conclusion:
Higher 24-h BP variability, but not BP level, was associated with cognitive decline. Prior to or in the early stages of cognitive decline, 24-h ambulatory BP monitoring might guide strategies to reduce the risk of major dementia-related disorders including Alzheimer's disease.
Recommended Citation
Melgarejo, J. D., Vatcheva, K. P., Mejia-Arango, S., Charisis, S., Patil, D., Mena, L. J., Garcia, A., Alliey-Rodriguez, N., Satizabal, C. L., Chavez, C. A., Gaona, C., Silva, E., Mavarez, R. P., Lee, J. H., Terwilliger, J. D., Blangero, J., Seshadri, S., & Maestre, G. E. (2024). Association of longitudinal changes in 24-h blood pressure level and variability with cognitive decline. Journal of hypertension, 42(11), 1985–1993. https://doi.org/10.1097/HJH.0000000000003824
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Journal of Hypertension
DOI
https://doi.org/10.1097/HJH.0000000000003824
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0