School of Medicine Publications and Presentations
Document Type
Article
Publication Date
9-2024
Abstract
Background
Observational assessments of infant temperament have provided unparalleled insight into prediction of risk for social anxiety. However, it is challenging to administer and score these assessments alongside high-quality infant neuroimaging data. In the current study, we aimed to identify infant resting-state functional connectivityassociated with both parent report and observed behavioral estimates of infant novelty-evoked distress.
Methods
Using data from the OIT (Origins of Infant Temperament) study, which includes deep phenotyping of infant temperament, we identified parent-report measures that were associated with observed novelty-evoked distress. These parent-report measures were then summarized into a composite score used for imaging analysis. Our infant magnetic resonance imaging sample was a synthetic cohort, harmonizing data from 2 functional magnetic resonance imaging studies of 4-month-old infants (OIT and BCP [Baby Connectome Project]; n= 101), both of which included measures of parent-reported temperament. Brain-behavior associations were evaluated using enrichment, a statistical approach that quantifies the clustering of brain-behavior associations within network pairs.
Results
Results demonstrated that parent-report composites of novelty-evoked distress were significantly associated with 3 network pairs: dorsal attention–salience/ventral attention, dorsal attention–default mode, and dorsal attention–control. These network pairs demonstrated negative associations with novelty-evoked distress, indicating that less connectivity between these network pairs was associated with greater novelty-evoked distress. Additional analyses demonstrated that dorsal attention–control network connectivity was associated with observed novelty-evoked distress in the OIT sample (n= 38).
Conclusions
Overall, this work is broadly consistent with existing work and implicates dorsal attention network connectivity in novelty-evoked distress. This study provides novel data on the neural basis of infant novelty-evoked distress.
Recommended Citation
Filippi, C. A., Winkler, A. M., Kanel, D., Elison, J. T., Hardiman, H., Sylvester, C., ... & Fox, N. A. (2024). Neural correlates of novelty-evoked distress in 4-month-old infants: A synthetic cohort study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Filippi, C. A., Winkler, A. M., Kanel, D., Elison, J. T., Hardiman, H., Sylvester, C., Pine, D. S., & Fox, N. A. (2024). Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study. Biological psychiatry. Cognitive neuroscience and neuroimaging, 9(9), 905–914. https://doi.org/10.1016/j.bpsc.2024.03.008
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Biological psychiatry. Cognitive neuroscience and neuroimaging
DOI
https://doi.org/10.1016/j.bpsc.2024.03.008
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2024 Society of Biological Psychiatry. http://creativecommons.org/licenses/by-nc-nd/4.0/