School of Medicine Publications and Presentations
Document Type
Article
Publication Date
10-23-2024
Abstract
Introduction: The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence-based, scalable culturally informed, community-engaged research (CI-CER) model and demonstrate its preliminary success in increasing URP enrollment.
Methods: URPs include ethnoculturally minoritized, lower education (≤ 12 years), and rural populations. The CI-CER model includes: (1) culturally informed methodology (e.g., less restrictive inclusion/exclusion criteria, sociocultural measures, financial compensation, results disclosure, Spanish Language Capacity Workgroup) and (2) inclusive engagement methods (e.g., the Engagement Core team; Hub Sites; Community-Science Partnership Board).
Results: As of April 2024, 60% of ADNI-4 new in-clinic enrollees were from ethnoculturally or educationally URPs. This exceeds ADNI-4's ≥ 50% URP representation goal for new enrollees but may not represent final enrollment.
Discussion: Findings show a CI-CER model increases URP enrollment in AD/ADRD clinical research and has important implications for clinical trials to advance health equity.
Highlights: The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) uses a culturally informed, community-engaged research (CI-CER) approach. The CI-CER approach is scalable and sustainable for broad, multisite implementation. ADNI-4 is currently exceeding its inclusion goals for underrepresented populations.
Recommended Citation
Rivera Mindt, M., Arentoft, A., Calcetas, A. T., Guzman, V. A., Amaza, H., Ajayi, A., Ashford, M. T., Ayo, O., Barnes, L. L., Camuy, A., Conti, C., Diaz, A., Easter, B., Gonzalez, D. J., Dotson, Y. G., Hoang, I., Germano, K. K., Maestre, G. E., Magaña, F., Meyer, O. L., … Alzheimer's Disease Neuroimaging Initiative (2024). The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity. Alzheimer's & dementia : the journal of the Alzheimer's Association, 10.1002/alz.14242. Advance online publication. https://doi.org/10.1002/alz.14242
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Alzheimer's & dementia : the journal of the Alzheimer's Association
DOI
https://doi.org/10.1002/alz.14242
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.