Uncovering the complex genetics of human personality: response from authors on the PGMRA Model

Authors

Igor Zwir
Pashupati Mishra
Coral Del-Val
C. Charles Gu
Gabriel A. de Erausquin, The University of Texas Rio Grande Valley
Terho Lehtimäki
C. Robert Cloninger

Document Type

Article

Publication Date

3-18-2019

Abstract

Following publication of our two articles [1, 2], a critique of the methodology of Phenotype-Genotype Many-to-Many Relations Analysis (PGMRA) [1, 3, 4] questioned the validity of our results from the perspective of polygenic risk scores (PRS) [5]. We appreciate the importance of these questions, and here provide a concise discussion of the assumptions and mathematical constraints of both approaches. We thank this commentator and others who have discussed our articles with us for their thoughtful questions and critiques.

Recommended Citation

Zwir, I., Mishra, P., Del-Val, C., Gu, C. C., de Erausquin, G. A., Lehtimäki, T., & Cloninger, C. R. (2020). Uncovering the complex genetics of human personality: Response from authors on the PGMRA Model. Molecular Psychiatry, 25(10), 2210–2213. https://doi.org/10.1038/s41380-019-0399-z

Publication Title

Molecular Psychiatry

DOI

10.1038/s41380-019-0399-z

Academic Level

faculty

Mentor/PI Department

Neuroscience