Following publication of our two articles [1, 2], a critique of the methodology of Phenotype-Genotype Many-to-Many Relations Analysis (PGMRA) [1, 3, 4] questioned the validity of our results from the perspective of polygenic risk scores (PRS) . We appreciate the importance of these questions, and here provide a concise discussion of the assumptions and mathematical constraints of both approaches. We thank this commentator and others who have discussed our articles with us for their thoughtful questions and critiques.
Zwir, I., Mishra, P., Del-Val, C., Gu, C. C., de Erausquin, G. A., Lehtimäki, T., & Cloninger, C. R. (2020). Uncovering the complex genetics of human personality: Response from authors on the PGMRA Model. Molecular Psychiatry, 25(10), 2210–2213. https://doi.org/10.1038/s41380-019-0399-z