Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance

Authors

Shabnam Malik, The University of Texas Rio Grande Valley
Mohammed Sikander, The University of Texas Rio Grande Valley
Mohd Wahid
Anupam Dhasmana, The University of Texas Rio Grande Valley
Maryam Sarwat
Sheema Khan, The University of Texas Rio Grande Valley
Everardo Cobos, The University of Texas Rio Grande Valley
Murali Yallapu, The University of Texas Rio Grande Valley
Meena Jaggi, The University of Texas Rio Grande Valley
Subhash Chauhan, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

9-2024

Abstract

There has been a surge of interest in recent years in understanding the intricate mechanisms underlying cancer progression and treatment resistance. One molecule that has recently emerged in these mechanisms is MUC13 mucin, a transmembrane glycoprotein. Researchers have begun to unravel the molecular complexity of MUC13 and its impact on cancer biology. Studies have shown that MUC13 overexpression can disrupt normal cellular polarity, leading to the acquisition of malignant traits. Furthermore, MUC13 has been associated with increased cancer plasticity, allowing cells to undergo epithelial-mesenchymal transition (EMT) and metastasize. Notably, MUC13 has also been implicated in the development of chemoresistance, rendering cancer cells less responsive to traditional treatment options. Understanding the precise role of MUC13 in cellular plasticity, and chemoresistance could pave the way for the development of targeted therapies to combat cancer progression and enhance treatment efficacy.

Comments

Reprints and permissions

Recommended Citation

Malik, S., Sikander, M., Wahid, M., Dhasmana, A., Sarwat, M., Khan, S., Cobos, E., Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2024). Deciphering cellular and molecular mechanism of MUC13 mucin involved in cancer cell plasticity and drug resistance. Cancer and Metastasis Reviews, 43(3), 981–999. https://doi.org/10.1007/s10555-024-10177-8

Publication Title

Cancer and Metastasis Reviews

DOI

https://doi.org/10.1007/s10555-024-10177-8

Academic Level

faculty