School of Medicine Publications and Presentations

Document Type

Article

Publication Date

11-1-2024

Abstract

Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals, marked by inflammation and the production of anti-tissue transglutaminase antibodies. Although CD patients often have lower body mass indexes and LDL levels, systemic inflammation can lead to endothelial dysfunction and accelerated atherosclerosis, potentially increasing the risk of coronary artery disease (CAD). We present a case of a 46-year-old female with CD who developed multivessel CAD, ultimately requiring coronary artery bypass grafting. This case highlights the significant cardiovascular risk associated with CD, suggesting that inflammation and genetic factors may contribute to atherosclerosis. While the precise mechanisms remain unclear, the findings underscore the need for vigilant cardiovascular monitoring in CD patients and further research to explore the impact of gluten-free diets on cardiovascular health.

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La enfermedad celíaca (EC) es un trastorno autoinmune desencadenado por la ingestión de gluten en individuos genéticamente predispuestos, caracterizado por inflamación y la producción de anticuerpos anti-transglutaminasa tisular. Aunque los pacientes con EC a menudo tienen índices de masa corporal y niveles de LDL más bajos, la inflamación sistémica puede llevar a disfunción endotelial y aterosclerosis acelerada, lo que podría aumentar el riesgo de enfermedad arterial coronaria (EAC). Presentamos el caso de una mujer de 46 años con EC que desarrolló EAC multivaso, lo que finalmente requirió un injerto de bypass coronario. Este caso resalta el significativo riesgo cardiovascular asociado con la EC, sugiriendo que la inflamación y los factores genéticos pueden contribuir a la aterosclerosis. Aunque los mecanismos precisos siguen siendo inciertos, los hallazgos subrayan la necesidad de una vigilancia cardiovascular atenta en los pacientes con EC y la necesidad de realizar más investigaciones para explorar el impacto de las dietas sin gluten en la salud cardiovascular.

Creative Commons License

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.

Publication Title

Revista de Medicina Clínica

DOI

10.5281/zenodo.14597569

Academic Level

resident

Mentor/PI Department

Internal Medicine

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