Gene-Environment Interactions in Non-alcoholic Fatty Liver Disease: Insights from Mexican American Populations

Authors

Eron G. Manusov, The University of Texas Rio Grande ValleyFollow
Vincent P. Diego, The University of Texas Rio Grande ValleyFollow
Marcio Almeida, The University of Texas Rio Grande ValleyFollow
Jacob Galan, The University of Texas Rio Grande ValleyFollow
Auwal A. Bala, The University of Texas Rio Grande Valley
Marco Arriaga, The University of Texas Rio Grande ValleyFollow
Natasha Garcia-Rodriguez, The University of Texas Rio Grande ValleyFollow
Renee Hernandez, The University of Texas Rio Grande Valley
Satish Kumar, The University of Texas Rio Grande Valley
John Blangero, The University of Texas Rio Grande ValleyFollow
Sarah Williams-Blangero, The University of Texas Rio Grande ValleyFollow

Document Type

Book Chapter

Publication Date

12-17-2024

Abstract

Nonalcoholic Fatty Liver Disease (NAFLD) is a prevalent and complex condition influenced by both genetic and environmental factors. This chapter explores the genotype-by-environment interactions that contribute to the development and progression of NAFLD in the Mexican American population. Using advanced genetic epidemiology and bioinformatics approaches, we investigated how specific genetic variants interact with environmental factors such as depression, acculturation stress, and social determinants of health, to influence NAFLD risk and severity. Our findings reveal significant genotype-by-environment interactions for key NAFLD-related traits, including HbA1c, AST/ALT ratio, and steatosis-controlled attenuation parameter (CAP). We also discuss the application of cutting-edge proteomic and transcriptomic techniques in identifying novel biomarkers and potential therapeutic targets for NAFLD. This comprehensive analysis provides insights into the molecular mechanisms of NAFLD in Mexican Americans and provides support for developing targeted prevention strategies and personalized healthcare.

Comments

© The Author(s). Licensee IntechOpen. This content is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Recommended Citation

Manusov, E. G., Diego, V. P., Almeida, M., Galan, J. A., Bala, A. A., Arriaga, M. A., Garcia-Rodriguez, N. S., Hernandez, R., Kumar, S., Blangero, J., Williams-Blangero, S., Manusov, E. G., Diego, V. P., Almeida, M., Galan, J. A., Bala, A. A., Arriaga, M. A., Garcia-Rodriguez, N. S., Hernandez, R., … Williams-Blangero, S. (2024). Gene-Environment Interactions in Non-alcoholic Fatty Liver Disease: Insights from Mexican American Populations. In J.-S. Kang (Ed.), A Comprehensive Guide to Non-alcoholic Fatty Liver Disease. IntechOpen. https://doi.org/10.5772/intechopen.1007926

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

A Comprehensive Guide to Non-alcoholic Fatty Liver Disease

DOI

10.5772/intechopen.1007926

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics