School of Medicine Publications
Document Type
Article
Publication Date
6-2025
Abstract
Recent high-throughput sequencing technologies have discovered various polymerase II transcribed transcripts. The majority of them are non-protein-coding, understudied, and poorly conserved. Noncoding transcripts are categorized based on their location in the genome and the direction in which they are transcribed; these categories classify a noncoding transcript as either antisense, intergenic, or divergent. The RNAs belonging to divergent classes consist of two transcripts, transcribed in sense and antisense direction, generated from the same promoter or locus. Multiple environmental and genetic cues can determine the regulation of these transcripts. One of the well-known signaling molecules, estrogen, has been shown to play a vital role in the activation and regulation of divergent transcripts by mediating effects through the estrogen receptors. Emerging studies have shown a strong causative effect between estrogen-regulated divergent transcripts and diseases such as cancer. However, few, viz., LncRNA67, CUPID1, and CUPID2, show a causal relationship with estrogen-dependent biology. This mini-review summarizes their role in estrogen-dependent processes that may drive the research to identify novel estrogen-signaling regulators.
Recommended Citation
Yang, B., Sedano, M. J., Diwa, K., Dominguez, J., Boisselier, G., Harrison, A. L., Reid, V. A., Ramos, E. I., Jimenez, M. V., Sanchez-Michael, L. A., Kolli, S., Patel, J., Lee, D., Vijayaraghavan, M., Chacon, J., Dhandayuthapani, S., & Gadad, S. S. (2025). A Snapshot of the Role of Estrogen-Regulated Divergent Non-Coding Transcripts. Clinical and translational discovery, 5(3), e70055. https://doi.org/10.1002/ctd2.70055
Publication Title
Clinical and translational discovery
DOI
10.1002/ctd2.70055
Academic Level
staff
Mentor/PI Department
Immunology and Microbiology
Comments
available on 2026-05-25