School of Medicine Publications and Presentations
Document Type
Article
Publication Date
5-2025
Abstract
Statin therapy is a highly successful and cost-effective strategy for the prevention and treatment of cardiovascular diseases (CVD). Adjusting for statin usage is crucial when exploring the association of the lipidome with CVD to avoid erroneous conclusions. However, practical challenges arise in real-world scenarios due to the frequent absence of statin usage information. To address this limitation, we demonstrate that statin usage can be accurately predicted using lipidomic data. Using three large population datasets and a longitudinal clinical study, we show that lipidomic-based statin prediction models exhibit high prediction accuracy in external validation. Furthermore, we introduce a re-weighted model, designed to overcome a ubiquitous limitation of prediction models, namely the need for predictor alignment between training and target data. We demonstrated that the re-weighted models achieved comparable prediction accuracy to ad hoc models which use the aligned predictor between training and target data. This innovation holds promise for significantly enhancing the transferability of statin prediction and other 'omics prediction models, especially in situations where predictor alignment is incomplete. Our statin prediction model now allows for the inclusion of statin usage in lipidomic analyses of cohorts even where statin use is not available, improving the interpretability of the resulting analyses.
Recommended Citation
Yi, C., Huynh, K., Schooneveldt, Y., Olshansky, G., Liang, A., Wang, T., Beyene, H. B., Dakic, A., Wu, J., Cinel, M., Mellett, N. A., Watts, G. F., Hung, J., Hui, J., Beilby, J., Curran, J. E., Blangero, J., Moses, E. K., Simes, J., Tonkin, A. M., … Meikle, P. J. (2025). Statin effects on the lipidome: Predicting statin usage and implications for cardiovascular risk prediction. Journal of lipid research, 66(5), 100800. https://doi.org/10.1016/j.jlr.2025.100800
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Journal of Lipid Research
DOI
10.1016/j.jlr.2025.100800
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2025 The Authors
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).