School of Medicine Publications and Presentations
Document Type
Article
Publication Date
7-16-2025
Abstract
We are currently in an exciting time to advance the field of renal endocrinology. There has never been a more favorable time to study the molecular and cellular mechanisms underlying renal hormone functions in physiology, pharmacology, and pathophysiology. The availability of advanced research tools provides unique opportunities to dissect the complex regulatory roles of renal hormones. The kidneys are vital organs in the human body; each one is composed of approximately one million functional nephrons. Understanding the precise roles and regulation of kidney-derived hormones and hormones that exert endocrine effects on the kidneys will help in preventing or delaying various renal and systemic diseases, including hypertensive complications. The primary functions of the kidneys include filtration of blood, maintenance of fluid, electrolyte and acid–base balances, controlling blood pressure, and facilitating erythropoiesis by generating erythropoietin. In addition to erythropoietin, kidneys also produce renin and help generate functional vitamin D by converting 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (1, 2). We briefly discuss the extrarenal functions of these kidney-derived factors below, with an emphasis on the clinical and functional aspects that remain to be elucidated.
Recommended Citation
Haque, E., & Razzaque, M. S. (2025). Specialty grand challenge: existing issues and emerging frontiers in renal endocrinology. Frontiers in Endocrinology, 16, 1651141. https://doi.org/10.3389/fendo.2025.1651141
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Frontiers in Endocrinology
DOI
10.3389/fendo.2025.1651141
Academic Level
faculty
Mentor/PI Department
Medical Education
Comments
© 2025 Haque and Razzaque. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)