School of Medicine Publications and Presentations
Document Type
Article
Publication Date
8-19-2025
Abstract
B complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy production. Thiamine is involved in the Krebs cycle, riboflavin in the electron transport chain, and niacin plays a key role in both glycolysis and the Krebs cycle. These metabolic processes are vital for sustaining the integrity of the nervous system, as the energy produced is critical for the functioning of nerve cells. Deficiencies in these vitamins can lead to significant neurological and psychiatric conditions, including Wernicke Korsakoff syndrome, Parkinson’s disease, and various mental illnesses. Additionally, pyridoxine (B6), folate (B9), and cobalamin (B12) are indispensable coenzymes for the methylation of homocysteine to methionine, a process critical to nervous system function. Elevated homocysteine levels, resulting from deficiencies of these vitamins, are associated with higher risks of depression and dementia. Thus, imbalances in these vitamins can disrupt key biochemical pathways, leading to neuropsychiatric disorders. The literature reviewed underscores the importance of daily intake of B complex vitamins to maintain normal serum levels and optimal neuronal function. This review aims to elucidate the neuropsychiatric manifestations associated with deficiencies in these vitamins.
Recommended Citation
Han, A., Almeida, L., Anand, N., Salloum, I., Kanaan, S., Gadad, B. S., & Daher, J. P. L. (2025). Exploring neuropsychiatric manifestations of vitamin B complex deficiencies. Frontiers in Psychiatry, 16, 1569826. https://doi.org/10.3389/fpsyt.2025.1569826
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
DOI
10.3389/fpsyt.2025.1569826
Academic Level
faculty
Mentor/PI Department
Medical Education
Comments
© 2025 Han, Almeida, Anand, Salloum, Kanaan, Gadad and Daher. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.