School of Medicine Publications
Document Type
Article
Publication Date
12-2025
Abstract
Recent advances in multi-omics and spatial proteomics are reshaping our understanding of Alzheimer's disease. Guo et al.1 applied integrative multi-omics to stratify mild cognitive impairment into biologically distinct subtypes with divergent progression trajectories: one metabolically impaired and slow-progressing, the other immune-activated and rapidly declining. Current techniques such as STC-DESI, LCM-MS, and machine learning enhance regional proteomic resolution, supporting biomarker discovery and spatially targeted interventions. This work exemplifies a broader shift toward precision medicine and a systems-level molecular framework in neurodegenerative disease research.
Recommended Citation
Perez-Navarro, L. M., & Lopez-Alvarenga, J. C. (2025). A molecular renaissance in Alzheimer's disease research: The rise of systems biology and spatial omics. Journal of Alzheimer's disease : JAD, 108(4), 1514–1516. https://doi.org/10.1177/13872877251387169
Publication Title
Journal of Alzheimer’s Disease
DOI
10.1177/13872877251387169
Academic Level
faculty
Mentor/PI Department
Population Health and Biostatistics
Comments
© The Author(s) 2025
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