School of Medicine Publications
Glucagon-Like Peptide-1: The Role of Calcium in Gut-Glucose Axis
Document Type
Book Chapter
Publication Date
2026
Abstract
Glucagon-like peptide-1 (GLP-1) is a key metabolic hormone secreted by intestinal L-cells in response to nutrient ingestion. It plays a central role in regulating glucose homeostasis by enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and suppressing appetite. While glucose, fat, and protein are established stimulators of GLP-1 release, calcium has emerged as a key modulator of this enteroendocrine axis. Recent studies have shown that extracellular calcium, acting through the calcium-sensing receptor (CaSR) and voltage-gated calcium channels, triggers intracellular calcium influx, which is essential for GLP-1 exocytosis from L-cells. This highlights the role of calcium not merely as a dietary mineral but as a signaling ion that links nutrient sensing in the gastrointestinal tract to the hormonal regulation of blood glucose homeostasis. This chapter briefly explains how calcium influences the GLP-1-mediated gut-glucose axis.
Recommended Citation
Foamkom, A. I., Abdelhady, H. G., & Razzaque, M. S. (2025). Glucagon-Like Peptide-1: The Role of Calcium in Gut-Glucose Axis. In Vitamin D Function: From Mineral Ion Regulation to Infection (pp. 127-131). Cham: Springer Nature Switzerland. https://doi.org/10.1007/978-3-032-04357-3_10
First Page
127
Last Page
131
Publication Title
Vitamin D Function: From Mineral Ion Regulation to Infection
DOI
10.1007/978-3-032-04357-3_10
Academic Level
faculty
Comments
© 2026 The Author(s), under exclusive license to Springer Nature Switzerland AG