School of Medicine Publications and Presentations
Document Type
Article
Publication Date
11-2-2020
Abstract
Nanomedicine is a rapidly growing field that uses nanomaterials for the diagnosis, treatment and prevention of various diseases, including cancer. Various biocompatible nanoplatforms with diversified capabilities for tumor targeting, imaging, and therapy have materialized to yield individualized therapy. However, due to their unique properties brought about by their small size, safety concerns have emerged as their physicochemical properties can lead to altered pharmacokinetics, with the potential to cross biological barriers. In addition, the intrinsic toxicity of some of the inorganic materials (i.e., heavy metals) and their ability to accumulate and persist in the human body has been a challenge to their translation. Successful clinical translation of these nanoparticles is heavily dependent on their stability, circulation time, access and bioavailability to disease sites, and their safety profile. This review covers preclinical and clinical inorganic-nanoparticle based nanomaterial utilized for cancer imaging and therapeutics. A special emphasis is put on the rational design to develop non-toxic/safe inorganic nanoparticle constructs to increase their viability as translatable nanomedicine for cancer therapies.
Recommended Citation
Damasco, J. A., Ravi, S., Perez, J. D., Hagaman, D. E., & Melancon, M. P. (2020). Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine. Nanomaterials, 10(11), 2186. https://doi.org/10.3390/nano10112186
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Nanomaterials
DOI
10.3390/nano10112186
Academic Level
medical student
Mentor/PI Department
Surgery
Comments
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.