School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2020
Abstract
Following publication of our two articles [1, 2], a critique of the methodology of Phenotype-Genotype Many-to-Many Relations Analysis (PGMRA) [1, 3, 4] questioned the validity of our results from the perspective of polygenic risk scores (PRS) [5]. We appreciate the importance of these questions, and here provide a concise discussion of the assumptions and mathematical constraints of both approaches. We thank this commentator and others who have discussed our articles with us for their thoughtful questions and critiques
Recommended Citation
Zwir, I., Mishra, P., Del-Val, C. et al. Uncovering the complex genetics of human personality: response from authors on the PGMRA Model. Mol Psychiatry 25, 2210–2213 (2020). https://doi.org/10.1038/s41380-019-0399-z
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Molecular Psychiatry
DOI
10.1038/s41380-019-0399-z
Academic Level
faculty
Mentor/PI Department
Psychiatry
Comments
© The Author(s) 2019.