School of Medicine Publications and Presentations
Document Type
Article
Publication Date
7-2018
Abstract
Here, we seek to summarize the current understanding of the biochemical and molecular events mediated by visual cycle molecules in the eye. The structures and functions of selected visual cycle proteins and their roles in human retinal diseases are also highlighted. Genetic mutations and malfunctions of these proteins provide etiological evidence that many ocular diseases arise from anomalies of retinoid (vitamin A) metabolism and related visual processes. Genetic retinal disorders such as retinitis pigmentosa, Leber's congenital amaurosis, and Stargardt's disease are linked to structural changes in visual cycle proteins. Moreover, recent reports suggest that visual cycle proteins may also play a role in the development of diabetic retinopathy. Basic science has laid the groundwork for finding a cure for many of these blindness-causing afflictions, but much work remains. Some translational research projects have advanced to the clinical trial stage, while many others are still in progress, and more are at the ideas stage and remain yet to be tested. Some examples of these studies are discussed. Recent and future progress in our understanding of the visual cycle will inform intervention strategies to preserve human vision and prevent blindness.
Recommended Citation
Tsin, A., Betts-Obregon, B., & Grigsby, J. (2018). Visual cycle proteins: Structure, function, and roles in human retinal disease. The Journal of biological chemistry, 293(34), 13016–13021. https://doi.org/10.1074/jbc.AW118.003228
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Journal of Biological Chemistry
DOI
10.1074/jbc.AW118.003228
Academic Level
faculty
Mentor/PI Department
Molecular Science
Comments
© 2018 Tsin et al. Original published version available at https://doi.org/10.1074/jbc.aw118.003228
Under a Creative Commons license