School of Medicine Publications and Presentations
Document Type
Article
Publication Date
8-2021
Abstract
Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications. This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches. It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents. This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.
Recommended Citation
Adriano, B., Cotto, N. M., Chauhan, N., Jaggi, M., Chauhan, S. C., & Yallapu, M. M. (2021). Milk exosomes: Nature's abundant nanoplatform for theranostic applications. Bioactive materials, 6(8), 2479–2490. https://doi.org/10.1016/j.bioactmat.2021.01.009
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Bioactive materials
DOI
10.1016/j.bioactmat.2021.01.009
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
© 2021 [The Author/The Authors].