Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Authors

Pradeep Natarajan
Akhil Pampana
Sarah E. Graham
Sanni Ruotsalainen
Paul S. de Vries
Jai G. Broome
Juan M. Peralta, The University of Texas Rio Grande Valley
John Blangero, The University of Texas Rio Grande Valley
Joanne E. Curran, The University of Texas Rio Grande ValleyFollow
James P. Pirruccello

Document Type

Article

Publication Date

2021

Abstract

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10-72), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls (P = 1.7 × 10-4), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls (P = 1.4 × 10-5). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.

Comments

Copyright © 2021, The Author(s)

Recommended Citation

Natarajan, P., Pampana, A., Graham, S. E., Ruotsalainen, S. E., Perry, J. A., de Vries, P. S., Broome, J. G., Pirruccello, J. P., Honigberg, M. C., Aragam, K., Wolford, B., Brody, J. A., Antonacci-Fulton, L., Arden, M., Aslibekyan, S., Assimes, T. L., Ballantyne, C. M., Bielak, L. F., Bis, J. C., Cade, B. E., … Peloso, G. M. (2021). Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nature communications, 12(1), 2182. https://doi.org/10.1038/s41467-021-22339-1

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Nat Commun

DOI

10.1038/s41467-021-22339-1

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics