School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2021
Abstract
Background: Very few studies have investigated the association between total plasma homocysteine (tHcy) and depressive symptoms in older Hispanics.
Objective: To test the hypothesis that high tHcy associates with depressive symptoms in older Hispanics.
Methods: A total of 1,418 participants .55 years old from the Maracaibo Aging Study (MAS) underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. The Neuropsychiatric Inventory Depression Subscale (NPId) was used to assess the burden of depressive symptoms. The tHcy levels and other biochemical parameters in blood samples were measured. Univariate and multivariate logistic regression models were applied.
Results: Participants with depressive symptoms had higher levels of tHcy than those without (15.1 versus 13.9 µmol/L; p = 0.009). Elevated tHcy levels were associated with depressive symptoms after adjusting for age, sex, education, smoking, diabetes, hypertension, alcohol intake, stroke, and dementia (OR = 1.58; 95% CI, 1.18-2.12).
Conclusion: Elevated levels of tHcy were associated with depressive symptoms in older Hispanics living under the nutritional and environmental conditions of a developing country.
Recommended Citation
Castro, F., Melgarejo, J., Chavez, C. A., de Erausquin, G. A., Terwilliger, J. D., Lee, J. H., & Maestre, G. E. (2021). Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics. Journal of Alzheimer's disease : JAD, 82(s1), S263–S269. https://doi.org/10.3233/JAD-201062
Publication Title
Journal of Alzheimer's Disease
DOI
10.3233/JAD-201062
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
Original published version available at https://doi.org/10.3233/JAD-201062