Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families

Authors

Hemant Kulkarni, The University of Texas Rio Grande Valley
Manju Mamtani, The University of Texas Rio Grande Valley
Gerard Wong
Jacquelyn M. Weir, Baker Heart and Diabetes Institute
Christopher K. Barlow
Thomas D. Dyer, The University of Texas Rio Grande Valley
Laura Almasy, The University of Texas Rio Grande Valley
Michael Mahaney, The University of Texas Rio Grande Valley
Anthony G. Comuzzie
Ravindranath Duggirala, The University of Texas Rio Grande Valley
Peter J. Meikle, Baker Heart and Diabetes Institute
John Blangero, The University of Texas Rio Grande Valley
Joanne E. Curran, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

5-19-2017

Abstract

Background

Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits.

Results

We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment – insulin resistance. We found that 44 lipid species were significantly genetically correlated with one or more of the three T2D-related traits. Majority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TAG, 17 species) classes. Six lipid species (all belonging to the triacylglycerol class and containing palmitate at the first position) were significantly genetically correlated with all the T2D-related traits.

Conclusions

Our results imply that: a) not all plasma lipid species are genetically informative for T2D pathogenesis; b) the DAG and TAG lipid classes partially share genetic basis of T2D; and c) 1-palmitate containing TAGs may provide additional insights into the genetic basis of T2D.

Comments

Copyright © 2017, The Author(s).

Recommended Citation

Kulkarni, H., Mamtani, M., Wong, G. et al. Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families. BMC Genet 18, 48 (2017). https://doi.org/10.1186/s12863-017-0515-5

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

BMC Genetics

DOI

10.1186/s12863-017-0515-5

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics